Proteinuria

Objectives
>* be able to differentiate between the three based off of light, electron, and immunofluorescent microscopy >* know common secondary causes of such diseases, such as toxins, infections, and systemic diseases; >* be familiar with the natural courses of minimal change disease and idiopathic membranous glomerulopathy >* Know the genetics of FSGS, and describe the mechanisms of scarring >* Know which of these syndromes are treatable.
 * Know the difference between nephrotic syndrome and nephritic syndrome
 * Be able to differentiate between nephrotic and nephritic syndromes based off urinalysis.
 * describe the microanatomy of the glomerular filtration barrier, and the rest of the glomerulus
 * know the normal mechanisms of protein re-absorption
 * describe conditions under which healthy individuals may have proteinuria
 * describe four common causitory mechanisms of proteinuria
 * know the various qualitative and quantitative assays for proteinuria, and the clinical significance thereof.
 * Explain why proteinuria occurs in nephrotic syndrome, and the mechanisms of the common sequelae: hypoalbuminemia, edema, and hyperlipidemia.
 * describe common complications of nephrotic syndrome
 * know the specific diseases commonly associated with nephrotic syndrome
 * For **minimal change disease, membranous glomerulopathy,** and **focal and segmental glomeruloschlerosis**:


 * describe common secondary treatments for nephrotic syndrome: ACE inhibition, blood pressure control, hyperlipidemic medications, protein restriction, et cetera ad nauseam.