Non-Opioid+Analgesics

=Acetaminophen= > No Gastric symptoms > No pyrolytic activity > No anti-inflammatory activity > No antiuricosuric (increasing uric acid secretion) activity > No anti-coagulant activity
 * Alternative to NSAIDs

> Normally minor product, but if microsomal pathway is overloaded, P450-dependent mechanism comes into play > hepatotoxic > if glutathione is depleted, liver damage will result > O/D traetment with emesis/lavalge and administration of N-acetetylcysteine
 * Rapidly absorbed orally
 * Metabolized in liver microsomes to sulfates, glucuronides
 * Overdose results in accumulation of N-acetyl-p-benzoquinone